Exercise 1 (7 points) Themes: exponential function, sequences In the context of a clinical trial, two treatment protocols for a disease are being considered. The objective of this exercise is to study, for these two protocols, the evolution of the quantity of medication present in a patient's blood as a function of time.
Parts $A$ and $B$ are independent
Part A: Study of the first protocol
The first protocol consists of having the patient take a medication in tablet form. The quantity of medication present in the patient's blood, expressed in mg, is modelled by the function $f$ defined on the interval $[0; 10]$ by $$f(t) = 3t \mathrm{e}^{-0.5t + 1},$$ where $t$ denotes the time, expressed in hours, elapsed since taking the tablet.
- a. It is admitted that the function $f$ is differentiable on the interval $[0; 10]$ and we denote $f'$ its derivative function. Show that, for every real number $t$ in $[0; 10]$, we have: $f'(t) = 3(-0.5t + 1)\mathrm{e}^{-0.5t + 1}$. b. Deduce the table of variations of the function $f$ on the interval $[0; 10]$. c. According to this model, after how much time will the quantity of medication present in the patient's blood be maximum? What is this maximum quantity?
- a. Show that the equation $f(t) = 5$ admits a unique solution on the interval $[0; 2]$ denoted $\alpha$, of which you will give an approximate value to $10^{-2}$ near. It is admitted that the equation $f(t) = 5$ admits a unique solution on the interval $[2; 10]$, denoted $\beta$, and that an approximate value of $\beta$ to $10^{-2}$ near is 3.46. b. It is considered that this treatment is effective when the quantity of medication present in the patient's blood is greater than or equal to 5 mg. Determine, to the nearest minute, the duration of effectiveness of the medication in the case of this protocol.
Part B: Study of the second protocol
The second protocol consists of initially injecting the patient, by intravenous injection, a dose of 2 mg of medication and then re-injecting every hour a dose of $1.8$ mg. It is assumed that the medication diffuses instantaneously into the blood and is then progressively eliminated. It is estimated that when one hour has elapsed after an injection, the quantity of medication in the blood has decreased by $30\%$ compared to the quantity present immediately after this injection. This situation is modelled using the sequence $(u_n)$ where, for every natural number $n$, $u_n$ denotes the quantity of medication, expressed in mg, present in the patient's blood immediately after the injection at the $n$-th hour. We therefore have $u_0 = 2$.
- Calculate, according to this model, the quantity $u_1$, of medication (in mg) present in the patient's blood immediately after the injection at the first hour.
- Justify that, for every natural number $n$, we have: $u_{n+1} = 0.7u_n + 1.8$.
- a. Show by induction that, for every natural number $n$, we have: $u_n \leqslant u_{n+1} < 6$. b. Deduce that the sequence $(u_n)$ is convergent. We denote its limit by $\ell$. c. Determine the value of $\ell$. Interpret this value in the context of the exercise.
- Consider the sequence $(v_n)$ defined, for every natural number $n$, by $v_n = 6 - u_n$. a. Show that the sequence $(v_n)$ is a geometric sequence with ratio 0.7 and specify its first term. b. Determine the expression of $v_n$ as a function of $n$, then of $u_n$ as a function of $n$. c. With this protocol, injections are stopped when the quantity of medication present in the patient's blood is greater than or equal to $5.5$ mg. Determine, by detailing the calculations, the number of injections carried out when applying this protocol.