Let $P(x)$ and $Q(x)$ be polynomials with real coefficients such that $P(x) + Q(x)$ is a second-degree polynomial and
$$\begin{aligned}
& P(x) \cdot Q(x) = -4 \cdot (x-1)^{4} \cdot (x-2)^{2} \\
& P(3) = -16
\end{aligned}$$
are satisfied.
Accordingly, what is the value of $Q(4)$?
A) 12
B) 24
C) 36
D) 48
E) 54